abstract：OBJECTIVE:To assess whether an assertive outreach intervention after suicide attempt could reduce the frequency of subsequent suicidal acts, compared with standard treatment. DESIGN:Randomised, parallel group, superiority trial with blinded outcome assessment. SETTING:Outpatient intervention at one location at Copenh...

journal_title：BMJ (Clinical research ed.)

authors： Morthorst B,Krogh J,Erlangsen A,Alberdi F,Nordentoft M

更新日期：2012-08-22 00:00:00

abstract：OBJECTIVE:To develop and validate a prognostic model for early death in patients with traumatic bleeding. DESIGN:Multivariable logistic regression of a large international cohort of trauma patients. SETTING:274 hospitals in 40 high, medium, and low income countries PARTICIPANTS:Prognostic model development: 20,127 t...

journal_title：BMJ (Clinical research ed.)

authors： Perel P,Prieto-Merino D,Shakur H,Clayton T,Lecky F,Bouamra O,Russell R,Faulkner M,Steyerberg EW,Roberts I

更新日期：2012-08-15 00:00:00

abstract：OBJECTIVE:To evaluate the association between migraine and cognitive decline among women. DESIGN:Prospective cohort study. SETTING:Women's Health Study, United States. PARTICIPANTS:6349 women aged 65 or older enrolled in the Women's Health Study who provided information about migraine status at baseline and particip...

journal_title：BMJ (Clinical research ed.)

authors： Rist PM,Kang JH,Buring JE,Glymour MM,Grodstein F,Kurth T

更新日期：2012-08-08 00:00:00

abstract：OBJECTIVES:To evaluate the risk of venous thromboembolic events associated with the use of progestin-only contraception and whether that risk differs with the mode of drug delivery (oral, intrauterine, or depot injection). DESIGN:Systematic review and meta-analysis of randomised controlled trials and observational stu...

journal_title：BMJ (Clinical research ed.)

authors： Mantha S,Karp R,Raghavan V,Terrin N,Bauer KA,Zwicker JI

更新日期：2012-08-07 00:00:00

abstract：OBJECTIVES:To evaluate the cardiac safety of central nervous system stimulants in children and adolescents. DESIGN:Population based retrospective cohort study. SETTING:Automated healthcare claims data from 1,219,847 children and young people eligible for 28 state Medicaid programmes from 1999 to 2006 linked to the So...

journal_title：BMJ (Clinical research ed.)

authors： Winterstein AG,Gerhard T,Kubilis P,Saidi A,Linden S,Crystal S,Zito J,Shuster JJ,Olfson M

更新日期：2012-07-18 00:00:00

abstract：OBJECTIVE:To assess the cost effectiveness of different screening strategies for abdominal aortic aneurysm in men, from the perspective of a national health service. SETTING:Screening units at regional hospitals. PARTICIPANTS:Hypothetical cohort of 65 year old men from the general population. MAIN OUTCOME MEASURES:C...

journal_title：BMJ (Clinical research ed.)

authors： Søgaard R,Laustsen J,Lindholt JS

更新日期：2012-07-05 00:00:00

abstract：OBJECTIVES:To develop prediction models that better estimate the pretest probability of coronary artery disease in low prevalence populations. DESIGN:Retrospective pooled analysis of individual patient data. SETTING:18 hospitals in Europe and the United States. PARTICIPANTS:Patients with stable chest pain without ev...

journal_title：BMJ (Clinical research ed.)

authors： Genders TS,Steyerberg EW,Hunink MG,Nieman K,Galema TW,Mollet NR,de Feyter PJ,Krestin GP,Alkadhi H,Leschka S,Desbiolles L,Meijs MF,Cramer MJ,Knuuti J,Kajander S,Bogaert J,Goetschalckx K,Cademartiri F,Maffei E,Martini

更新日期：2012-06-12 00:00:00

abstract：OBJECTIVE:To determine the clinical and cost effectiveness of booklet based vestibular rehabilitation with and without telephone support for chronic dizziness, compared with routine care. DESIGN:Single blind, parallel group, pragmatic, randomised controlled trial. SETTING:35 general practices across southern England ...

journal_title：BMJ (Clinical research ed.)

authors： Yardley L,Barker F,Muller I,Turner D,Kirby S,Mullee M,Morris A,Little P

更新日期：2012-06-06 00:00:00

abstract：OBJECTIVE:To determine whether women with atrial fibrillation have a higher risk of stroke than men. DESIGN:Nationwide retrospective cohort study. SETTING:Patients with a diagnosis of atrial fibrillation in the Swedish hospital discharge register between 1 July 2005 and 31 December 2008. Information about drug treatm...

journal_title：BMJ (Clinical research ed.)

authors： Friberg L,Benson L,Rosenqvist M,Lip GY

更新日期：2012-05-30 00:00:00

abstract：OBJECTIVE:To examine the effectiveness of post-diagnosis dementia treatment and coordination of care by memory clinics compared with general practitioners. DESIGN:Multicentre randomised controlled trial. SETTING:Nine memory clinics and 159 general practitioners in the Netherlands. PARTICIPANTS:175 patients with a ne...

journal_title：BMJ (Clinical research ed.)

authors： Meeuwsen EJ,Melis RJ,Van Der Aa GC,Golüke-Willemse GA,De Leest BJ,Van Raak FH,Schölzel-Dorenbos CJ,Verheijen DC,Verhey FR,Visser MC,Wolfs CA,Adang EM,Olde Rikkert MG

更新日期：2012-05-15 00:00:00

abstract：OBJECTIVE:To evaluate the effectiveness of neuromuscular training in reducing the rate of acute knee injury in adolescent female football players. DESIGN:Stratified cluster randomised controlled trial with clubs as the unit of randomisation. SETTING:230 Swedish football clubs (121 in the intervention group, 109 in th...

journal_title：BMJ (Clinical research ed.)

authors： Waldén M,Atroshi I,Magnusson H,Wagner P,Hägglund M

更新日期：2012-05-03 00:00:00

abstract：OBJECTIVES:To compare the clinical and cost effectiveness of total hip arthroplasty with resurfacing arthroplasty in patients with severe arthritis of the hip. DESIGN:Single centre, two arm, parallel group, assessor blinded, randomised controlled trial with 1:1 treatment allocation. SETTING:One large teaching hospita...

journal_title：BMJ (Clinical research ed.)

authors： Costa ML,Achten J,Parsons NR,Edlin RP,Foguet P,Prakash U,Griffin DR,Young Adult Hip Arthroplasty Team.

更新日期：2012-04-19 00:00:00

abstract：OBJECTIVE:To determine whether the use of the UK clinical aptitude test (UKCAT) in the medical schools admissions process reduces the relative disadvantage encountered by certain sociodemographic groups. DESIGN:Prospective cohort study. SETTING:Applicants to 22 UK medical schools in 2009 that were members of the cons...

journal_title：BMJ (Clinical research ed.)

authors： Tiffin PA,Dowell JS,McLachlan JC

更新日期：2012-04-17 00:00:00

abstract：OBJECTIVE:To determine whether cognitive therapy is effective in preventing the worsening of emerging psychotic symptoms experienced by help seeking young people deemed to be at risk for serious conditions such as schizophrenia. DESIGN:Multisite single blind randomised controlled trial. SETTING:Diverse services at fi...

journal_title：BMJ (Clinical research ed.)

authors： Morrison AP,French P,Stewart SL,Birchwood M,Fowler D,Gumley AI,Jones PB,Bentall RP,Lewis SW,Murray GK,Patterson P,Brunet K,Conroy J,Parker S,Reilly T,Byrne R,Davies LM,Dunn G

更新日期：2012-04-05 00:00:00

abstract：OBJECTIVES:To summarise evidence on the association between white rice consumption and risk of type 2 diabetes and to quantify the potential dose-response relation. DESIGN:Meta-analysis of prospective cohort studies. DATA SOURCES:Searches of Medline and Embase databases for articles published up to January 2012 using...

journal_title：BMJ (Clinical research ed.)

authors： Hu EA,Pan A,Malik V,Sun Q

更新日期：2012-03-15 00:00:00

abstract：OBJECTIVES:To relate cancer since entry into the Framingham Heart Study with the risk of incident Alzheimer's disease and to estimate the risk of incident cancer among participants with and without Alzheimer's disease. DESIGN:Community based prospective cohort study; nested age and sex matched case-control study. SET...

journal_title：BMJ (Clinical research ed.)

authors： Driver JA,Beiser A,Au R,Kreger BE,Splansky GL,Kurth T,Kiel DP,Lu KP,Seshadri S,Wolf PA

更新日期：2012-03-12 00:00:00

abstract：OBJECTIVE:To identify and estimate the population costs and effects of a selected set of enforcement strategies for reducing the burden of road traffic injuries in developing countries. DESIGN:Cost effectiveness analysis based on an epidemiological model. SETTING:Two epidemiologically defined World Health Organizatio...

journal_title：BMJ (Clinical research ed.)

authors： Chisholm D,Naci H,Hyder AA,Tran NT,Peden M

更新日期：2012-03-02 00:00:00

abstract：OBJECTIVE:To evaluate the effectiveness and costs of a multifaceted flexible educational programme aimed at reducing antibiotic dispensing at the practice level in primary care. DESIGN:Randomised controlled trial with general practices as the unit of randomisation and analysis. Clinicians and researchers were blinded ...

journal_title：BMJ (Clinical research ed.)

authors： Butler CC,Simpson SA,Dunstan F,Rollnick S,Cohen D,Gillespie D,Evans MR,Alam MF,Bekkers MJ,Evans J,Moore L,Howe R,Hayes J,Hare M,Hood K

更新日期：2012-02-02 00:00:00

abstract：OBJECTIVE:To compare characteristics of patients and outcomes after elective surgery in independent sector treatment centres (ISTCs) and NHS providers. DESIGN:Follow-up study with outcomes reported by patients three to six months after surgery. SETTING:25 ISTCs and 72 NHS providers in England. Population Consecutive ...

journal_title：BMJ (Clinical research ed.)

authors： Chard J,Kuczawski M,Black N,van der Meulen J,POiS Audit Steering Committee.

更新日期：2011-10-19 00:00:00

abstract：OBJECTIVES:To estimate life expectancy for people with HIV undergoing treatment compared with life expectancy in the general population and to assess the impact on life expectancy of late treatment, defined as CD4 count <200 cells/mm(3) at start of antiretroviral therapy. DESIGN:Cohort study. SETTING:Outpatient HIV c...

journal_title：BMJ (Clinical research ed.)

authors： May M,Gompels M,Delpech V,Porter K,Post F,Johnson M,Dunn D,Palfreeman A,Gilson R,Gazzard B,Hill T,Walsh J,Fisher M,Orkin C,Ainsworth J,Bansi L,Phillips A,Leen C,Nelson M,Anderson J,Sabin C

更新日期：2011-10-11 00:00:00

abstract：OBJECTIVES:To investigate patients' and family members' perceptions and experiences of disclosure of healthcare incidents and to derive principles of effective disclosure. DESIGN:Retrospective qualitative study based on 100 semi-structured, in depth interviews with patients and family members. SETTING:Nationwide mult...

journal_title：BMJ (Clinical research ed.)

authors： Iedema R,Allen S,Britton K,Piper D,Baker A,Grbich C,Allan A,Jones L,Tuckett A,Williams A,Manias E,Gallagher TH

更新日期：2011-07-25 00:00:00

abstract：OBJECTIVE:To examine the associations of a vegetarian diet and dietary fibre intake with risk of diverticular disease. DESIGN:Prospective cohort study. SETTING:The EPIC-Oxford study, a cohort of mainly health conscious participants recruited from around the United Kingdom. PARTICIPANTS:47,033 men and women living in...

journal_title：BMJ (Clinical research ed.)

authors： Crowe FL,Appleby PN,Allen NE,Key TJ

更新日期：2011-07-19 00:00:00

abstract：OBJECTIVE:To identify the factors associated with diabetic ketoacidosis at diagnosis of type 1 diabetes in children and young adults. DESIGN:Systematic review. DATA SOURCES:PubMed, EMBASE, Web of Science, Scopus, and Cinahl and article reference lists. STUDY SELECTION:Cohort studies including unselected groups of ch...

journal_title：BMJ (Clinical research ed.)

authors： Usher-Smith JA,Thompson MJ,Sharp SJ,Walter FM

更新日期：2011-07-07 00:00:00

abstract：OBJECTIVE:To determine the association of resting echocardiography before elective intermediate to high risk non-cardiac surgery with survival and length of hospital stay. DESIGN:Population based retrospective cohort study. SETTING:Acute care hospitals in Ontario, Canada, between 1 April 1999 and 31 March 2008. PART...

journal_title：BMJ (Clinical research ed.)

authors： Wijeysundera DN,Beattie WS,Karkouti K,Neuman MD,Austin PC,Laupacis A

更新日期：2011-06-30 00:00:00

abstract：OBJECTIVES:To assess the compliance of Asian intensive care units and hospitals to the Surviving Sepsis Campaign's resuscitation and management bundles. Secondary objectives were to evaluate the impact of compliance on mortality and the organisational characteristics of hospitals that were associated with higher compli...

journal_title：BMJ (Clinical research ed.)

authors： Phua J,Koh Y,Du B,Tang YQ,Divatia JV,Tan CC,Gomersall CD,Faruq MO,Shrestha BR,Gia Binh N,Arabi YM,Salahuddin N,Wahyuprajitno B,Tu ML,Wahab AY,Hameed AA,Nishimura M,Procyshyn M,Chan YH,MOSAICS Study Group.

更新日期：2011-06-13 00:00:00

abstract：OBJECTIVE:To compare the clinical effectiveness of cryotherapy versus salicylic acid for the treatment of plantar warts. DESIGN:A multicentre, open, two arm randomised controlled trial. SETTING:University podiatry school clinics, NHS podiatry clinics, and primary care in England, Scotland, and Ireland. PARTICIPANTS:...

journal_title：BMJ (Clinical research ed.)

authors： Cockayne S,Hewitt C,Hicks K,Jayakody S,Kang'ombe AR,Stamuli E,Turner G,Thomas K,Curran M,Denby G,Hashmi F,McIntosh C,McLarnon N,Torgerson D,Watt I,EVerT Team.

更新日期：2011-06-07 00:00:00

abstract：OBJECTIVE:To determine how length of anticoagulation and clinical presentation of venous thromboembolism influence the risk of recurrence after anticoagulant treatment is stopped and to identify the shortest length of anticoagulation that reduces the risk of recurrence to its lowest level. DESIGN:Pooled analysis of in...

journal_title：BMJ (Clinical research ed.)

authors： Boutitie F,Pinede L,Schulman S,Agnelli G,Raskob G,Julian J,Hirsh J,Kearon C

更新日期：2011-05-24 00:00:00

abstract：OBJECTIVE:To compare the efficacy of surgery with disc prosthesis versus non-surgical treatment for patients with chronic low back pain. DESIGN:A prospective randomised multicentre study. SETTING:Five university hospitals in Norway. PARTICIPANTS:173 patients with a history of low back pain for at least one year, Osw...

journal_title：BMJ (Clinical research ed.)

authors： Hellum C,Johnsen LG,Storheim K,Nygaard OP,Brox JI,Rossvoll I,Rø M,Sandvik L,Grundnes O,Norwegian Spine Study Group.

更新日期：2011-05-19 00:00:00

abstract：OBJECTIVE:To undertake a cost effectiveness analysis comparing first and second generation endometrial ablative techniques, hysterectomy, and the levonorgestrel releasing intrauterine system (Mirena) for treating heavy menstrual bleeding. DESIGN:Model based economic evaluation with data from an individual patient data...

journal_title：BMJ (Clinical research ed.)

authors： Roberts TE,Tsourapas A,Middleton LJ,Champaneria R,Daniels JP,Cooper KG,Bhattacharya S,Barton PM

更新日期：2011-04-26 00:00:00

abstract：OBJECTIVE:To assess the cost-effectiveness of low dose statins for primary prevention of vascular disease, incorporating current prices, non-adherence (reduced clinical efficacy while maintaining healthcare costs), and the results of the recently published JUPITER trial. DESIGN:Cost-effectiveness analysis using a Mark...

journal_title：BMJ (Clinical research ed.)

authors： Greving JP,Visseren FL,de Wit GA,Algra A

更新日期：2011-03-30 00:00:00

abstract：OBJECTIVE:To systematically determine the impact of growth hormone therapy on adult height of children with idiopathic short stature. DESIGN:Systematic review. DATA SOURCES:Cochrane Central Register of Controlled Trials, Medline, and the bibliographic references from retrieved articles of randomised and non-randomise...

journal_title：BMJ (Clinical research ed.)

authors： Deodati A,Cianfarani S

更新日期：2011-03-11 00:00:00

abstract：OBJECTIVE:To independently evaluate the impact of the second phase of the Health Foundation's Safer Patients Initiative (SPI2) on a range of patient safety measures. Design A controlled before and after design. Five substudies: survey of staff attitudes; review of case notes from high risk (respiratory) patients in med...

journal_title：BMJ (Clinical research ed.)

authors： Benning A,Dixon-Woods M,Nwulu U,Ghaleb M,Dawson J,Barber N,Franklin BD,Girling A,Hemming K,Carmalt M,Rudge G,Naicker T,Kotecha A,Derrington MC,Lilford R

更新日期：2011-02-03 00:00:00

abstract：OBJECTIVE:To assess the impact of a pay for performance incentive on quality of care and outcomes among UK patients with hypertension in primary care. DESIGN:Interrupted time series. SETTING:The Health Improvement Network (THIN) database, United Kingdom. PARTICIPANTS:470 725 patients with hypertension diagnosed betw...

journal_title：BMJ (Clinical research ed.)

authors： Serumaga B,Ross-Degnan D,Avery AJ,Elliott RA,Majumdar SR,Zhang F,Soumerai SB

更新日期：2011-01-25 00:00:00

abstract：OBJECTIVE:To derive and validate an algorithm to estimate the absolute risk of having ovarian cancer in women with and without symptoms. DESIGN:Cohort study with data from 375 UK QResearch general practices for development and 189 for validation. PARTICIPANTS:Women aged 30-84 without a diagnosis of ovarian cancer at ...

journal_title：BMJ (Clinical research ed.)

authors： Hippisley-Cox J,Coupland C

更新日期：2011-01-04 00:00:00

abstract：OBJECTIVE:To compare the effectiveness of elective single embryo transfer versus double embryo transfer on the outcomes of live birth, multiple live birth, miscarriage, preterm birth, term singleton birth, and low birth weight after fresh embryo transfer, and on the outcomes of cumulative live birth and multiple live b...

journal_title：BMJ (Clinical research ed.)

authors： McLernon DJ,Harrild K,Bergh C,Davies MJ,de Neubourg D,Dumoulin JC,Gerris J,Kremer JA,Martikainen H,Mol BW,Norman RJ,Thurin-Kjellberg A,Tiitinen A,van Montfoort AP,van Peperstraten AM,Van Royen E,Bhattacharya S

更新日期：2010-12-21 00:00:00

abstract：OBJECTIVES:To prospectively assess the diagnostic performance of simple ultrasound rules to predict benignity/malignancy in an adnexal mass and to test the performance of the risk of malignancy index, two logistic regression models, and subjective assessment of ultrasonic findings by an experienced ultrasound examiner ...

journal_title：BMJ (Clinical research ed.)

authors： Timmerman D,Ameye L,Fischerova D,Epstein E,Melis GB,Guerriero S,Van Holsbeke C,Savelli L,Fruscio R,Lissoni AA,Testa AC,Veldman J,Vergote I,Van Huffel S,Bourne T,Valentin L

更新日期：2010-12-14 00:00:00

abstract：OBJECTIVE:To determine whether the author's 20.9 lb (9.5 kg) carbon frame bicycle reduced commuting time compared with his 29.75 lb (13.5 kg) steel frame bicycle. DESIGN:Randomised trial. SETTING:Sheffield and Chesterfield, United Kingdom, between mid-January 2010 and mid-July 2010. PARTICIPANTS:One consultant in an...

journal_title：BMJ (Clinical research ed.)

authors： Groves J

更新日期：2010-12-09 00:00:00

abstract：OBJECTIVES:To see whether telling peer reviewers that their signed reviews of original research papers might be posted on the BMJ's website would affect the quality of their reviews. DESIGN:Randomised controlled trial. SETTING:A large international general medical journal based in the United Kingdom. PARTICIPANTS:54...

journal_title：BMJ (Clinical research ed.)

authors： van Rooyen S,Delamothe T,Evans SJ

更新日期：2010-11-16 00:00:00

abstract：OBJECTIVE:To compare incidences of perinatal mortality and severe perinatal morbidity between low risk term pregnancies supervised in primary care by a midwife and high risk pregnancies supervised in secondary care by an obstetrician. DESIGN:Prospective cohort study using aggregated data from a national perinatal regi...

journal_title：BMJ (Clinical research ed.)

authors： Evers AC,Brouwers HA,Hukkelhoven CW,Nikkels PG,Boon J,van Egmond-Linden A,Hillegersberg J,Snuif YS,Sterken-Hooisma S,Bruinse HW,Kwee A

更新日期：2010-11-02 00:00:00

abstract：OBJECTIVE:To determine whether a decision aid designed for adults with low education and literacy can support informed choice and involvement in decisions about screening for bowel cancer. DESIGN:Randomised controlled trial. SETTING:Areas in New South Wales, Australia identified as socioeconomically disadvantaged (lo...

journal_title：BMJ (Clinical research ed.)

authors： Smith SK,Trevena L,Simpson JM,Barratt A,Nutbeam D,McCaffery KJ

更新日期：2010-10-26 00:00:00